SUTYKINE 12.5MG (7,S STRIP)

Introduction:

SUTYKINE 12.5 CAPSULE contains Sunitinib which belongs to the group of medicines called Protein Kinase Inhibitors. It is used in the treatment of gastrointestinal stromal tumor (GIST) (a type of cancer of the stomach and bowel) where another anticancer medicine (imatinib) no longer works or you cannot take it and metastatic renal cell carcinoma (MRCC) (type of kidney cancer that has spread to other parts of the body).

SUTYKINE 12.5 CAPSULE is also used to treat pancreatic neuroendocrine tumors (pNET) (tumors of the hormone-producing cells in the pancreas) that have progressed or cannot be removed with surgery. Your doctor might ask you to take blood tests, check your blood pressure and take your ECG during treatment with SUTYKINE 12.5 CAPSULE and as clinically indicated.

Before taking SUTYKINE 12.5 CAPSULE, inform your doctor if you have heart, kidney, liver, blood, thyroid, or pancreatic problems, seizures, and diabetes or if you recently had or are going to undergo any surgery. Ask your doctor before taking SUTYKINE 12.5 CAPSULE during pregnancy. You should not breastfeed while taking SUTYKINE 12.5 CAPSULE so, consult your doctor before taking it. It is not known if SUTYKINE 12.5 CAPSULE is safe and effective in children and it should be used with caution in elderly patients (65 years and above).

Instructions:

Your doctor or nurse will give you this medicine. Kindly do not self-administer. Swallow with enough water. Do not crush or chew it. Your doctor will decide the correct dose and duration of SUTYKINE 12.5 CAPSULE treatment depending on your age, body weight  and disease condition. 

• A gastrointestinal stromal tumor (GIST)
• Metastatic renal cell carcinoma (MRCC)
• Pancreatic neuroendocrine tumors (pNET)

Side Effects:

COMMON

• Reduced Platelets, Red Blood Cells, or White Blood Cells
• Shortness of breath
• High Blood Pressure
• Extreme tiredness, weakness
• Swelling due to fluid under the skin and around the eye, deep allergic rash
• Upset stomach, nausea, vomiting, diarrhea, constipation, stomach pain/swelling, loss of appetite
• Mouth pain/irritation, mouth sores/inflammation/dryness, taste disturbances
• Decreased thyroid activity
• Dizziness, headache
• Nose bleeding
• Pain in joints, back, arms, legs
• Yellow skin/skin discoloration, excess pigmentation of the skin, hair color change, rash on the palms of the hands and soles of the feet, dry skin
• Cough, fever
• Difficulty sleeping
• Deficiency of blood supply to the heart muscle, obstruction or constriction of the coronary arteries, chest pain, and decrease in the amount of blood pumped by the heart.

UNCOMMON

• Serious soft tissue infection including the anogenital area
• Stroke
• Heart problems (heart attack, abnormal heart rhythm, fluid around the heart)
• Liver failure
• Inflamed pancreas (stomach pain)
• Gallbladder inflammation (swelling and redness) with or without associated gallstones
• Abnormal tubes like a passage from one normal body cavity to another body cavity or the skin
• Osteonecrosis (pain in the mouth, teeth, or jaw, swelling or sores inside the mouth, numbness or a feeling of heaviness in the jaw or loosening of a tooth)
• Overactive thyroid increases the amount of energy used by the body at rest
• An increased blood level of a muscle enzyme (creatine phosphokinase)
• Allergic reaction to an allergen (hay fever, skin rash or itching, hives, swelling of body parts, trouble breathing)
• Inflammation of the colon (colitis, colitis ischemic

RARE

• Tumor lysis syndrome (nausea, breathlessness, irregular heartbeat, muscular cramps, fits, clouding of urine, tiredness associated with abnormal laboratory test results)
• Abnormal muscle breakdown
• Abnormal changes in the brain (headache, confusion, fits, vision loss)
• Painful skin ulceration
• Inflammation of the liver or thyroid gland
• Thrombotic microangiopathy (scarring of the smallest blood vessels

Stop taking SUTYKINE 12.5 CAPSULE and contact your doctor immediately if you experience any of the following side effects:

• Heart problems like heart failure and heart muscle problems (feeling very tired or breathless, swollen feet and ankles)
• Lung or breathing problems like pulmonary embolism (cough, chest pain, sudden onset of breathlessness, coughing up blood)
• Kidney disorders like kidney failure (altered frequency or absence of urination)
• Bleeding problems (painful, swollen stomach, vomiting blood, black, sticky stools, bloody urine, headache, change in the mental status, coughing up blood or bloody sputum from the lungs or airway)
• Tumor destruction leading to a hole in the intestine (severe abdominal pain, fever, nausea, vomiting, blood in your stool, change in bowel habits)
• Blood clot in blood vessels (chest pain or pressure, pain in your arms, back, neck or jaw, breathlessness, numbness or weakness on one side of your body, trouble talking, headache or dizziness)
• Getting tired more easily, feeling colder than other people, voice deepening
• Skin conditions like pyoderma gangrenosum or necrotizing fasciitis (fever, pain, redness, swelling, drainage of pus or blood)
• Toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome (reddish target-like spots or circular patches often with central blisters on the trunk, the rash that may progress to widespread blistering or peeling of the skin)
• Low blood sugar (fatigue, throbbing sensation, sweating, hunger)
• Severe liver problems (itching, yellow eyes or skin, dark urine, pain or discomfort in the right upper stomach area)
• Protein in urine
• Wound healing problems