PAZINIB 200MG (30's TAB)

Introduction:

PAZINIB 200 TABLET contains Pazopanib which belongs to the group of medicines called Protein kinase inhibitors. It is used in the treatment of kidney cancer (that has advanced or spread to other organs) and soft tissue sarcoma. 

Soft tissue sarcoma is a type of cancer that affects the supportive tissues of the body. It can occur in the muscles, blood vessels, fat tissues or other tissues that support, surround and protect the organs.Your doctor may ask you to undergo certain diagnostic tests to check the functioning of your liver, kidney and heart and may monitor your blood pressure prior to and while you take PAZINIB 200 TABLET. 

Before taking [GBNKEWYORD], consult with your doctor if you have any heart, kidney or liver diseases, had lung problems, thyroid problems, bleeding or blood clotting issues, stomach or bowel problems (perforation or fistula), aneurysm (enlargement and weakening of a blood vessel wall) or have high blood pressure.

PAZINIB 200 TABLET is not recommended in pregnant and breastfeeding women. PAZINIB 200 TABLET is not recommended in children and adolescents below 18 years of age. Consult with your doctor before taking PAZINIB 200 TABLET.

Instructions:

Your doctor or nurse will give you this medicine. Kindly do not self-administer. Take PAZINIB 200 TABLET as advised by your doctor. Swallow PAZINIB 200 TABLET along with a glass of water. Do not crush or chew the medicine. Your doctor will decide the proper dose and duration of PAZINIB 200 TABLET for you depending on your age, body weight, and disease condition.

Treats:

• Kidney cancer
• Sarcoma (cancer that begins in bones or in any soft tissues of the body)
  
  

Side Effects:

COMMON

• High blood pressure
• Diarrhoea
• Nausea or vomiting
• Stomach pain
• Loss of appetite
• Weight loss
• Taste disturbance or loss of taste
• Sore mouth
• Headache
• Tumor pain
• Inadequate energy, weakness, or tiredness
• Hair color changes, unusual loss of hair, or hair thinning
• Skin pigment loss
• Skin rash, peeling off the skin, skin burning, prickling, itching, or tingling sensation
• Redness and swelling in the hands or soles of the feet
• Signs of decrease in albumin in the blood (weakness and exhaustion)

UNCOMMON

• Stroke (due to blood clot)
• Short-term fall in the supply of blood to the brain (transient ischaemic attack)
• Obstruction of blood supply to part of the heart or heart attack (myocardial infarction)
• Partial obstruction of the supply of blood to part of the heart (myocardial ischemia)
• Blood clots are associated with a decrease in red blood cells and cells involved in clotting (thrombotic microangiopathy) which causes harm to the brain and kidneys
• Signs of increased red blood cells (such as shortness of breath, fatigue, and joint pain)
• Sharp chest pain or fast breathing (pulmonary embolism)
• Severe bleeding in the digestive system (such as stomach, esophagus, or intestine), or in the kidneys, vagina, and brain, hole (perforation) in the stomach or intestine
• Heart rhythm disturbance (QT prolongation)
• Abnormal passages forming between parts of the intestine (fistula)
• Heavy or irregular menstrual periods
• A sharp and sudden increase in blood pressure (hypertensive crisis)
• Signs of pancreas inflammation (pancreatitis) such as abdominal pain
• Signs of liver inflammation (such as nausea, fatigue)
• Skin or whites of the eyes become yellow in color (jaundice)
• Inflammation of the abdominal cavity lining (peritonitis)
• Runny nose

RARE

• Inflammation of the lung (pneumonitis)
• Enlarged and weakened blood vessel wall or blood vessel wall tear (aneurysms and artery dissections)

Stop taking PAZINIB 200 TABLET and consult with your doctor if you experience any of the following symptoms:

• Signs of swelling of the brain (loss of speech, change of vision, seizure (fits), confusion, high blood pressure)
• Signs of a sudden and severe rise in blood pressure (severe chest pain, severe headache, blurred vision, confusion, nausea, vomiting, severe anxiety, shortness of breath, fainting)
• Signs of heart failure or heart attack (irregular or fast heartbeat, rapid fluttering of your heart, fainting, chest pain or pressure, painful arms, back, neck or jaw, leg swelling)
• Signs of stroke (one side of your body becomes weak and numb, difficulty talking, headache, dizziness)
• Signs of e severe bleeding in the digestive system or the lungs, kidneys, mouth, vagina, and brain (black stools or stools with blood, urine with blood, painful stomach, coughing or vomiting up blood)
• Signs of a tear (perforation) stomach or intestinal wall or the development of an abnormal connection between two parts of your digestive tract (a fistula) (severe stomach pain, fever, hole formation (perforation) in the stomach, intestine or bowel from which pus is released which is bloody and has foul smell)
• Signs of liver problems (yellowing of your skin or the whites of your eyes (jaundice), dark urine, tiredness, loss of appetite, pain on the right side of your stomach area (abdomen), bruising easily)
• Signs of formation of a blood clot (sharp chest pain, rapid breathing, leg pain, swelling of arms and hands or legs and feet, bruising easily, high blood pressure, drowsiness, decrease in urine output)
• Signs of tumor lysis syndrome (fast breakdown of tumor cells) such as irregular heartbeat, seizures (fits), confusion, muscle cramps or spasms or decrease in urine output